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KMID : 0379520030190020123
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한국독성학회지
2003 Volume.19 No. 2 p.123 ~ p.131
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Combined Repeated Dose and Reproductive/Developmental Toxicities of Benzoyl Peroxide
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Song Sang-Hwan
Kim Su-Hyon
Bae Hee-Kyung
Kim Mi-Kyung
Koo Hyun-Ju
Park Kwang-Sik
Lee Sang-Kyun
Park Joong-Hoon
Choi Eun-Sil
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Abstract
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This study was carried out to assess the combined repeated dose, reproduction and developmental toxicities of benzoyl peroxide for OECD SIDS (Screening Information Data Set) program. Male and female Sprague-Dawley rats were exposed to benzoyl peroxide at dose levels of 0, 250, 500 and 1,000 mg/kg/day for 29 days for males and for 41-51 days for females. No deaths were found in all animals including control group during exposure period. No hematological effects attributable to benzoyl peroxide were observed in all treated groups. Significant decrease in the weight of testes and epididymis were observed in males at 1,000 mg/kg/day. In females at 1,000 mg/kg/day, slight histopathological effects in uterus such as epithelial vacuolation or hyperplasia were observed. No treatment-related changes in precoital time and rate of copulation, fertility and gestation period were noted in all treated groups. There was no evidence of teratogenic effect of benzoyl peroxide, but body weight of pups at 1,000 mg/kg/day was significantly decreased. NOAEL for combined repeated dose and reproduction/developmental toxicity was 500 mg/kg/day.
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KEYWORD
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Benzoyl peroxide, Combined repeated dose, Reproduction and developmental toxicity, NOAEL, SIDS
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